aAPC: Artificial APC APC: Antigen-presenting cell AuNP: Gold nanoparticle ASPIRE: Antigen self-presentation and immunosuppression reversal BC: Breast cancer BN: Bavarian Nordic CAF: Cancer-associated fibroblast CNP: Carbon nanoparticle CNS: Central nervous system CpG: Cytosine–phosphate–gu...
Additionally, NK cells augment the anti-tumor activity of adaptive immune cells via cytokine secretion. However, metabolic interference in the form of lactic acid accumulation within the TME reduces intracellular pH in NK cells, inducing pH-dependent mitochondrial stress and metabolic disruption, ...
Globally, one-third of children younger than 5 years old experience some form of malnutrition [7]. In low-income and middle-income regions, nutritional health has become increasingly unaffordable for millions of children. Children are often in a vulnerable position in the allocation of resources ...
At the end of the last century, adoptive cell therapies (ACT) using autologous peripheral lymphocytes or tumor-infiltrating lymphocytes (TILs) after stimulation and expansion by lymphokines have been widely attempted in the clinical setting. However, significant clinical effects were only achieved in ce...
E APC and AAPC for tuberculosis temporal trends in eight high-burden countries. APC annual percentage change; AAPC average annual percentage change; DRC the Democratic Republic of the Congo Full size image Effects of age, period and birth cohort on TB incidence for eight high-burden countries ...
PE-labeled rat-anti-human IgG1/3 antibody was used to detect the binding of PD-L1 to the cells. The mean fluorescence intensity of cells was measured by a flow cytometer and analyzed by FlowJo (V10.6). For reporter assay, human PD-L1 aAPC/CHO-K1 cells were incubated in a 96-well ...
This condition may generate more complex clinical demands for higher levels of technological density and cost due to the chronic form of the disease complications, particularly chronic chagasic heart disease or digestive system diseases. [10, 16, 38, 39]. Over the two decades analysed, there was...
One common goal of a case/control genome wide association study (GWAS) is to find SNPs associated with a disease. Traditionally, the first step in such studies is to assign a genotype to each SNP in each subject, based on a statistic summarizing fluoresc
These limitations contribute to the time-consuming and resource-intensive nature of T cell activation and proliferation in vitro. Importantly, through careful modification and decoration, nanoparticles (NPs) can be tuned to serve as aAPC platforms. Nanoscale aAPC, such as biodegradable nanoellipsoidal ...
8) [314]. PDT is a local treatment that employs photosensitizers, which is a drug that becomes activated to produce a form of oxygen to kills nearby cells when exposed to light. By combining PDT with immune agents, the anti-cancer efficiency can be further enhanced. To improve the immune ...