Integrin alpha 5 (ITGA5) was previously confirmed to be related to prognosis in several cancer types; however, its function in clear cell renal cell carcinoma (ccRCC) and how this molecule regulates tumor progression and the tumor microenvironment (TME) remain to be elucidated. Methods We investi...
such as the poor prognosis in nasopharyngeal carcinoma with dual epithelial–immune characteristics have been discovered [14]. Similarly, strong epithelial-to-mesenchymal transition (EMT) and stemness signatures were observed in metastatic breast cancer cells [15,16]. With...
Second, each LLi is assigned a different weight, which makes the method more flexible in practice. Third, with linearization, the linear inverse operator commonly existent in the previous methods solving inverse problems [14, 18,19,20,21,22] is avoided, and thus, the one-step efficiency is ...
Previous work has established that CSCs may originate from malignant transformation of adult stem cells [10] or epithelial–mesenchymal transition (EMT) dedifferentiation of cancer cells [11]. Recently, it has been found that differentiated cells can be transformed into CSCs with carcinogenicity by end...
of EMT process [120]. T790M mutation detection by simultaneously capturing and interrogating exosomal RNA/DNA and cfDNA (exoNA) had 92% sensitivity and 89% specificity using results of tumor biopsy as gold standard [26]. Another qPCR- based test that assessed mutations within EGFR using exoNA ...
SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis Yixun Zhang, Yumeng Yang, Xuan Qi, Peng Cui, Yi Kang, Haiyi Liu, Zhigang Wei & Haibo Wang Journal of Experimental & Clinical Cancer Research volume 43, Article number: 208 (2024)...
On the other hand, down-regulated genes in NSCLC-H cell line were associated with the differentiative status of epithelial cells, supporting evidence of a partial epithelial-to-mesenchymal transition (EMT) in NSCLC-H cells (Additional file 5: Figure S1B-ii.). Up-regulated genes were enriched...
This discovery emphasizes the pivotal role of neutrophils in osteoarthritis development, offering a theoretical foundation for advancing more focused treatment strategies in clinical practice. Therapeutic effects of extracellular vesicles derived from mesenchymal stem cells have been observed in osteoarthritis, ...
XIST transcript, a long non-coding RNA, was downregulated in cancer cells that specifically metastasizes to the brain and not bone, promoting EMT and activation of c-MET. Loss of XIST induced the expression of miR-503 that decreases the M1-M2 polarization of the microglia leading to stunted ...
It has also been found to facilitate PCa metastasis by promoting angiogenesis and EMT [32]. These findings collectively underscore the pivotal role of angiogenesis in PCa metastasis. Functional analysis revealed a significant correlation between metastasis-related genes and the activation of Hormone AR....