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Cancer immunotherapy has sparked a wave of cancer research, driven by recent successful proof-of-concept clinical trials. However, barriers are emerging during its rapid development, including broad adverse effects, a lack of reliable biomarkers, tumor r
Skin cancer (SC), is one of the most devastating cancers of the present decade, and the fifth commonest form of cancer [1,2,3]. It is further predicted to surpass heart disease as the main cause of mortality and the biggest obstacle to extending life expectancy in the next decades. Acc...
Full-text screening was performed in a blinded fashion by two reviewers (MSA and MSK), with disagreements being settled by discussion with a senior author (FRP). Papers were divided into four categories: established cell line models (ECLM), primary patient-derived tumor models (PTM), ...
By extension of this concept, the human-on-a-chip modular microfluidic devices can be built by combining multiple organ chips, where each chip can mimic each part of the human body. Compared with an integrated multiorgan-on-a-chip plate, connecting individual organ chips is more flexible to ...
“Now, I am truly me”: accepting my body to reclaim my sexuality Improvements in body self-perception and increased self-esteem directly influence the sexuality of women who undergo bariatric surgery. Two subthemes were developed from the data analysis. The body as the focal point of sexuality...
Skin and Appendages: Rash, maculopapular rash. Less Common Adverse Reactions (< 1%) Body As a Whole: Ecchymosis, fever, headache, malaise. Cardiovascular: Necrotizing angiitis, vasculitis, pericarditis, peripheral vascular disease, thrombophlebitis, bradycardia, vasodilation. ...
It is the only screening tool proven to reduce breast cancer mortality, detecting cancers up to 10 years earlier than physical exams. Clinical Breast Exams (CBEs) involve a physical examination by a healthcare professional, but their benefit is unclear when combined with regular mammography. ...
For the purpose of selecting an optimal number of pre-selected CpGs, we performed a screening using Generation Scotland as our training cohort and GSE40279 (one of the largest external datasets with a wide age range) as our test set. Our analyses showed that the 10,000 most significant loci...
They created 18 unique LNPs (A1–A18) via definitive screening design (DSD). Factors included ionizable lipid type (C12-200, DLin-MC3-DMA), phospholipid type (DSPC, DOPE), and various molar percentages of lipids and cholesterol. Key metrics measured were hydrodynamic diameter (72.2–171.5 nm...