To investigate the correlation between hyperlipidemia and knee OA, patients with obesity or hyperlipidemia were strictly distinguished in this study to eliminate their mutual influence. It was found that compared with OA patients with normal weight and blood lipids, OA patients with hyperlipidemia had ...
For more than a year after she’d been cleared of heartworm, she’d come on walks with us and, while there would be panic moments here and there and, at times, an especially bad walk where I really wondered if walks were the right thing for her, for the most part, she did just f...
The emergence of antimicrobial resistance is a major threat to global health and has placed pressure on the livestock industry to eliminate the use of antibiotic growth promotants (AGPs) as feed additives. To mitigate their removal, efficacious alternatives are required. AGPs are thought to operate...
Family Movie Night was about as democratic as it gets, which means that if I had to sit through Soccer Dog: European Cup and suffer the unrelenting vulgarity (and grudging hilarity) of Dumb and Dumber, then in turn my sons had to put up with my fondness for classics like Annie, School ...
Citizen science can be a powerful approach to foster the successful implementation of technological innovations in health, care or well-being. Involving experience experts as co-researchers or co-designers of technological innovations facilitates mutual learning, community building, and empowerment. By util...
A cell’s epigenome arises from interactions among regulatory factors—transcription factors and histone modifications—co-localized at particular genomic regions. We developed a novel statistical method, ChromNet, to infer a network of these interaction
Activator protein (AP)-1 and nuclear factor (NF)-κB largely control T-cell activation, following binding of foreign antigens to the T-cell receptor leading to cytokine secretion. Elevated levels of pro-inflammatory cytokines and chemokines such as TNF, IL-6 and CXCL8 are associated with sever...
we collected 341 mutated and CNV genes from 91 GBM samples that have been re-sequenced in that study. A total of 237 of these genes (70%) were in the FI network. Of these, 168 have mutual FIs and are interconnected. We built a subnetwork around these 168 genes, applied the edge-betw...
(23%) genes with NMs from the analysis. We then predicted the effect of 57 genes with single frame-shifting indel and 74 genes with a single NM. Analysis of genes with more than one form of variation requires considering mutual effects of variations on function that is the subject of our...
Given the mutual interest in developing a common definition, ParticipACTION and HALO collaborated to orchestrate the development of a common definition of physical literacy and consensus statement. Purpose The purpose of this paper is to describe the processes employed to develop and release Canada’s...