FTY720-Mitoxy normalized movement, sweat function and soleus muscle mass in 11.5 mo Tg MSA mice. FTY720-Mitoxy also increased levels of brain GDNF and reduced brain miR-96-5p, a miRNA that acts to decrease GDNF expression. Moreover, FTY720-Mitoxy blocked aSyn pathology measured by sequential...
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Using mouse, rat, dog, monkey, and human liver microsomes the intrinsic clearance of FTY720-C2 was 22.5, 79.5, 6.0, 20.2 and 18.3 μL/min/mg; and for FTY720-Mitoxy was 1.8, 7.8, 1.4, 135.0 and 17.5 μL/min/mg, respectively. In hepatocytes, both FTY720-C2 and FTY720-Mitoxy were ...
FTY720, FTY720-C2, and FTY720-Mitoxy all prevented oxidative-stress-associated-cell-death of OLN-93 cells that lack any aSyn expression. However, only FTY720-Mitoxy protected MSA-like aSyn-expressing-OLN-93-cells against oxidative-cell-death. These data identify potent protective effects for ...
FTY720-Mitoxy Basic information Product Name: FTY720-Mitoxy Synonyms: FTY 720 Mitoxy;FTY720 Mitoxy;FTY720Mitoxy;FTY-720-Mitoxy;FTY720-Mitoxy;FTY720 Mitoxy,FTY720Mitoxy CAS: 1604816-11-6 MF: C40H51BrNO3P MW: 704.73 EINECS: Product Categories: Mol File: 1604816-11-6.mol FTY720-Mitoxy ...
FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.doi:10.1016/j.expneurol.2019.113120Guadalupe Vidal-MartinezIsmael Segura-Ulate...
Parkinson’s diseasemultiple system atrophyFTY720FTY720-Mitoxytransgenic mouse modelsParkinson's disease (PD) and multiple system atrophy (MSA) patients often suffer from gastrointestinal (GI) dysfunction and GI dysbiosis (microbial imbalance). GI dysfunction also occurs in mouse models of PD and ...
Basic informationSupplier 1604816-11-6 Basic informationMore Product Name:FTY720-Mitoxy Synonyms:FTY 720 MitoxyFTY720 MitoxyFTY720MitoxyFTY-720-MitoxyFTY720-MitoxyFTY720 Mitoxy,FTY720Mitoxy CAS:1604816-11-6 MF:C40H51BrNO3P MW:704.73 EINECS: ...