摘要:近日,一篇发表在国际杂志《Nature Cancer》上的研究报告中,来自美国威尔康乃尔医学院等机构的科学家们揭示了一种特殊的防御机 近日,一篇发表在国际杂志《Nature Cancer》上的研究报告中,来自美国威尔康乃尔医学院等机构的科学家们揭示了一种特殊的防御机制,该机制能保护黑色素瘤细胞免受氧化性压力的影响,从而帮助...
Cancer geneticsNon-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. The mechanisms underlying NSCLC tumorigenesis are incompletely understood. Transfer RNA (tRNA) modification is emerging as a novel regulatory mechanism for carcinogenesis. However, the role of tRNA ...
FTSJ1 downregulation enhanced glycolytic metabolism of non-small cell lung cancer (NSCLC) cells, as indicated by increased levels of lactate, pyruvate, and extracellular acidification rate (ECAR). Whereas treatment with glycolytic inhibitor 2-DG reversed this effect. In contrast, upregulation of FTS...
The knockdown of FTSJ1 inhibits TNBC cell proliferation and development, induces apoptosis of cancer cells, and increases the sensitivity of TNBC cells to T-cell-mediated cytotoxicity. Furthermore, the high expression of FTSJ1 in TNBC attenuates CD8 T cell infiltration in the tumor microenvironment ...