K Lysates from transfected HEK 293 T cells with Myc-tagged USP7 (WT) or Myc-tagged USP29 (C223S), together with HA-tagged Ub and Flag-tagged FTO, were generated after immunoprecipitation with anti-Flag and immunoblotting with anti-HA and anti-Flag. L The Myc-USP7, Flag-FTO and the...
Accession code: Miccroarray data generated by hybridization of RNA from both FTO1_C1 and FTO2_D4 clones with and without induced expression as well as from FTO siRNA- and scrampled siRNA-treansfected cells can be obtained from Gene Expression Omnibus (GSE33870). URL: GeneTrail gene set ...
Mice constitutively expressing two additional copies of FTO in all tissues on a C57BL/6J background (FTO-4) were generated by insertion of the FTO cDNA into a pCAGGs-STOP-EGFP-ROSA-TV plasmid (downstream of the STOP cassette). Targeted stem cell injections were given to C57BL/6J ...
FTO mediates CRC cells ferroptosis Given that FTO expression is downregulated during CRC ferroptotic cell death, we assumed that FTO may be a negative regulator of ferroptosis. Indeed, we found that knockdown FTO augmented MDA levels, and decreased the glutathione/glutathione (GSH/GSSG) ratio (Fig...
Therefore, an in-depth understanding of the pathogenesis of t(8;21) AML will aid in improving personalized clinical interventions. The AML1-ETO fusion protein, generated by the t(8;21)(q22;q22) chromosomal translocation, plays the pivotal role in the initiation of t(8;21) AML. AML1-ETO...
The experimental data were representative of three independent experiments at least, and the GraphPad Prism software (version 9.0 for Windows) was used for calculations and generated the statistical graph. The differences between two groups were analyzed using two-tailed t-tests. One-way analysis of...
Availability of data and materials All datasets generated in this study was accessible upon reasonable requirement.Change history 30 August 2020 A Correction to this paper has been published: https://doi.org/10.1186/s12935-020-01473-8 References Ferlay J, Soerjomataram I, Dikshit R, Eser S, ...
However, the TiO2 nanoparticles tended to be agglomerated on the nanorods' surface when the TIO volume was further increased above 290 µL. Therefore, TIO must play an important role in the formation of the nanoparticles on the nanorod arrays (Figure 1c) [13]. On the contrary, the ...
Chameleon equips you with 3 different classes of flat color schemes that can be generated from a flat or non-flat color. In the examples below, the white stars indicate the color used to generate the schemes. Analogous Flat Color Scheme Complementary Flat Color Scheme Triadic Flat Color Scheme...
[kəmˈpjuːtər ˈlɪtərəsi skɪlz] - 计算机技能computer-generated imagery [kəmˈpjuːtərˌdʒɛnəreɪtɪd ˈɪmədʒri] - 计算机生成的图像computer processing speed [kəmˈpjuːtər ˈproʊsɛsɪŋ spid] - 计算机处理...