Destruction of FSP1-expressing cells by conditional diphtheria toxin activity in FSP1-Cre;R26RDTA mice resulted in severe TMJ osteoarthritis with loss of the cartilage structure. Lgr5-expressing cells in the superficial layer of the condyle have been shown to create a Wnt inhibitory niche. FSP1 ...
Human cartilage and mouse chondrocyte experiments revealed that additional treatment with FSP1 and CoQ10 abated osteoarthritis (OA) development in Col2a1-CreERT GPX4flox/flox (GPX4-CKO) mice [74]. Ginsenoside Rg1 alleviated sepsis-induced acute kidney injury (AKI), possibly resulting from the ...
Four month-old Sirt1-LKO mice and their age-matched littermate Lox controls (Cre−/−, Sirt1flox/flox) were fasted for 15 h overnight, and euthanized at ZT3. Glycemia was assessed in mice using an Ascencia Elite XL glucometer and strips (Bayer) to measure glucose in the blood ...
Eric G. Neilson from Vanderbilt University (Nashville, TN) for his kind providing FSP1-GFP reporter, FSP1 KO, and FSP1-Cre mice as well as the anti-FSP1 Ab. Prof. Richard Boyd (Monash University) for his kind offering anti-MTS15 mAb, Prof. Francois-Xavier Hubert (Walter and Eliza...