6-bisphosphatase (PFK-2/FBPase-2) was preceded by the discovery of its product fructose-2,6-bisphosphate (F2,6BP). This sugar was first identified as the mediator responsible for stimulating hepatic gluconeogenesis. It had been known for some time that gluconeogenesis was induced in liver by e...
The interaction of AMP and fructose 2,6-bisphosphate with rabbit liver fructose-1,6-bisphosphatase has been investigated by proton nuclear magnetic resonance spectroscopy (1H NMR). The temperature dependence of the line widths of the proton resonances of AMP as a function of fructose-1,6-...
An enzyme that catalyzes the stoichiometric conversion of fructose 2,6-bisphosphate into fructose 6-phosphate and inorganic phosphate has been purified from rat liver. This fructose 2,6-bisphosphatase copurified with phosphofructokinase 2 (ATP: D-fructose 6-phosphate 2-phosphotransferase) in the several...
The present review addresses recent advances in research into a family of bifunctional enzymes that are responsible for the twofold task of synthesizing and hydrolyzing fructose-2,6-bisphosphate (Fru-2,6-P2), which in turn regulates the rate of glycolysis in most cells. The structure of the syn...
We identified a point mutation in FBP1 that renders it insensitive to AMP while sparing regulation by fructose-2,6-bisphosphate (F-2,6-P2), and knock-in (KI) of this mutant in mice significantly reduces their response to metformin treatment. We observe this during a metformin tolerance test...
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism. Cancer Metab 2013; 1: 8. Article Google Scholar Chesney J, Clark J, Klarer AC, Imbert-Fernandez Y, Lane AN, Telang S . Fructose-2,6-bisphosphate synthesis by 6-phosphofructo...
Effect of normothermic perfusion using fructose-1,6-bisphosphate for maintenance of liver function during in situ extended hepatectomy by the total hepatic... The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections (HAI). HAI affect approxi...
- 《Gene An International Journal Focusing on Gene Cloning & Gene Structure & Function》 被引量: 107发表: 2012年 Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction? In numerous cell types, tumoral cells, proliferating cells...
Fructose 2,6-bisphosphate (F26P) is an allosteric activator of 6-phosphofructo-1-kinase (PFK1) and a negative regulator of fructose-1,6-bisphosphatase (FBP) that are key regulatory steps controlling glycolysis and gluconeogenesis, respectively (6, 7). By reducing the levels of F26P, TIGAR ...
Activation of Ras by Fru1,6bisP.aRas-GTP level 3 min after addition of 5 mM of different glycolytic metabolites to permeabilized yeast spheroplasts. Glu6P, glucose-6-phosphate; Tre6P, trehalose-6-phosphate; Fru6P, fructose-6-phosphate; Fru1,6bisP, fructose-1,6-bisphosphate; DHAP, dihydrox...