After several decades, therapeutic cancer vaccines now show signs of efficacy and potential to help patients resistant to other standard-of-care immunotherapies, but they have yet to realize their full potential and expand the oncologic armamentarium. He
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically recognized for its role in the regulation of toxicity mediated by environmental chemicals. Recent research points to AhR's critical participation in male reproductive physiology, particularly in spermatogenesis, ...
prompting scientists to explore their use in cancer therapy. Novel cancer treatments in the form of cancer vaccines have been developed based on the previously mentioned types of vaccines. The goal of these vaccines is to trigger either humoral or cellular immune reactions ...
Recently, there has been an explosion of new work with regard to the therapeutic application of proresolving ligands in experimental atherosclerosis. Therefore, this review will highlight recent advances in our understanding of how inflammation resolution may become defective in atherosclerosis and the ...
iRT has yet to achieve groundbreaking progress, however, numerous issues remain to be resolved in future. Primarily, the abscopal effect was predominantly recognized, yet the impact of iRT on the TME and the potential mechanism by which it induces abscopal effects on tumors remains elusive [25,...
TNF-α Tumor necrosis factor α WAT White adipose tissue α-KG α-ketoglutarate Keywords Natural products Immunometabolism Macrophages Metabolic diseases Metabolic pathways 1. Introduction Immunometabolism is an emerging discipline that lies at the intersection of immunology and metabolic biology, playing a ...
In a multivariate model, MSM was the only variable that remained associated with reporting anonymous sex as a risk factor at the time of infection (OR 3.4 CI: 1.9–6.0; p < 0.0001). However, the proportion of MSM who reported anonymous sex was similar to that of individuals who were...
iRT has yet to achieve groundbreaking progress, however, numerous issues remain to be resolved in future. Primarily, the abscopal effect was predominantly recognized, yet the impact of iRT on the TME and the potential mechanism by which it induces abscopal effects on tumors remains elusive [25,...
Tanyi, J. L. et al. Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.Sci. Transl. Med.10, eaao5931 (2018). Wculek, S. K. et al. Dendritic cells in cancer immunology and immunotherapy.Nat. Rev. Immunol.20, 7–24 (2020). ...
Importantly, either serum SAA alone, serum SAA in complex with HDL, or HDL alone has enhanced certain neutrophil responses to influenza A infection (M. R. White et al., 2021). The findings suggest that SAA may exert a dual impact on influenza infection. Firstly, it might diminish the ...