2005. From in vivo to in vitro/in silico ADME: Progress and challenges. Expert Opin Drug Metab Toxicol 1:1-4.Van de Waterbeemd, H. (2005). "From in vivo to in vitro/in silico ADME: progress and challenges." Expert opinion on drug metabolism & toxicology. 1(1): 1-4....
Amid growing efforts to advance the replacement, reduction, and refinement of the use of animals in research, there is a growing recognition that in vitro testing of medical devices can be more effective, both in terms of cost and time, and also more reliable than in vivo testing. Although ...
From in vitro to in vivo: Intracellular determination of imatinib and nilotinib may be related with clinical outcome 来自 国家科技图书文献中心 喜欢 0 阅读量: 15 作者:Bouchet,Dulucq,Pasquet,J.-M.,Lagarde,Molimard,Mahon,F.-X.摘要: Imatinib (Glivec or Gleevec) is an inhibitor of BC ...
Bouchet S, Dulucq S, Pasquet JM, Lagarde V, Molimard M, and Mahon FX (2013) From in vitro to in vivo: intracellular determination of imatinib and nilotinib may be related with clinical outcome. Leukemia 27:1757-1759.Bouchet S, Dulucq S, Pasquet JM, Lagarde V, Molimard M and Mahon ...
Furthermore, in-vivo studies were performed in order to examine the fate/ transit of formulations in gastrointestinal tract of albino rats, to validate the in-vitro methodology. However, these findings confirmed its applicability as a promising device for targeting of 5-FU at desirable site of ...
A guide to the use of pore-forming toxins for controlled permeabilization of cell membranes Gadeberg OV, Orskov I (1984) In vitro cytotoxin effect of alpha-hemolytic Escherichia coli on human blood granulocytes. Infect Immun 45: 255–259 Geoff... S Bhakdi,U Weller,I Walev,... - 《Med ...
The in vitro and in vivo activities of a mixture of six oleane triterpene saponins, recovered from the methanolic extract of the leaves of the Vietnamese plant Maesa balansae (PX-6518), were evaluated against drug-sensitive visceral Leishmania strains. The in vitro 50% inhibitory concentration ...
Background This study evaluated the in vitro and in vivo antiplasmodial activity of extracts from V. amygdalina leaves. The plant was selected based on local claims on its efficacy as part of the treatment regimen in malarial infection in the south - western region of Nigeria. Materials and ...
Trimethadione (TMO) has the properties required of a probe drug for the evaluation of hepatic drug-oxidizing capacity and, in this study, we have summarized the in vivo and in vitro metabolism of TMO in various animal species including mouse, hamster, rat, rabbit, dog, monkey and human. ...
Results showed that both the proanthocyaidins from LSPC and LSHPC were able to significantly inhibit proliferation of B16 cells in vitro, and the inhibition rates were 87.4% and 78.2%, respectively. The morphological alterations of melanoma B16 cell membrane damage caused by them were observed....