, F32GM119191 (to O. S. F.), and GM111097 (to B. M. H.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National ...
This work was supported by the NIH R01 GM114671 (D.A.F.), the Immunotherapeutics and Vaccine Research Initiative at University of California, Berkeley (D.A.F.), and the Chan Zuckerberg Biohub (D.A.F.). M.D.V. was funded by a Burroughs Wellcome Fund CASI Fellowship. D.A.F. is ...
and peptide metabolite concentrations, indicating that toxin activity induces an altered gut metabolic profile11. Although a nutritional generalist,C. difficileis auxotrophic and requires multiple amino acids, including the branched-chain amino acids and proline that are used in Stickland metabolism for ...
Mid1 shuttles in and out of the nucleus via its multiple nuclear localization and export sequences [7, 11]. To address the possibility that Mid1-9A has increased cortical localization because it cannot be imported into the nucleus, we constructed a strain defective in Mid1 nuclear import. Pur...