Drug Development from Target Selection to Clinical Proof of Concept - A Plan for Small MoleculesPresident, VicePrograms, Drug Development
Nanotherapeutic platforms for cancer treatment: From preclinical development to clinical application. In Nanoarchitectonics for Smart Delivery and Drug Targeting; Grumezescu, A., Holban, A.M., Eds.; Elsevier: Amsterdam, The Netherlands, 2016; pp. 813-869....
aA drug emerging from clinical development and on the cusp of commercialization may be to a considerable extent an unknown quantity to potential prescribers. Medical Affairs spearheads efforts to explain its "real world" utility through the dissemination of unbiased clinical and scientific information ...
Immune rejection has limited the clinical application of skin transplantation [131]. Conventional strategies for large organ transplantation involve lifelong immunosuppressant treatment, which compromises the immune system and increases the risk of microbial infection and tumorigenesis. As a result, progress ...
Belatacept: from rational design to clinical applicationbelataceptcostimulation blockadeCTLA4Ig immunosuppressionrenal transplantationGradually improved immunosuppression has contributed significantly to the progress achieved in transplantation medicine so far. Nevertheless, current drug regimens are associated with late...
Chinese innovative drug R&D trends in 2024 Zimeng Chen Hui Zhong Guanqiao Li From the Analyst's Couch31 Jul 2024 The changing landscape of cancer cell therapies: clinical trials and real-world data Ana Rosa Saez-Ibañez Samik Upadhaya ...
COMMENTARY page XX REVIEW Autophagy: from basic science to clinical application J Van Limbergen1,2,3, C Stevens4, ER Nimmo1, DC Wilson2,3 and J Satsangi1 Autophagy is a cellular pathway involved in protein and organelle degradation, which is likely to represent an innate adaptation to ...
(the discovery phase). The developmental medicinal product would then be progressed into nonclinical studies to demonstrate safety and provide an initial indication of mode of action supportive of clinical trials in patients. If a clinical trial application (CTA)...
From previous related studies, it is clear that the application of MDA alone for the prevention and control of schistosomiasis in Africa cannot completely eliminate the dis- ease; hence, we should not only treat patients, but also pay attention to comprehensive management methods, such as snail ...
Dove Medical PressDrug Design, Development and TherapyQian, J. et al. A clinical prognostic scoring system for resectable gastric cancer to predict survival... Y Shu,Q Jing,Y Qian,... - 《Drug Design Development & Therapy》 被引量: 13发表: 2016年 drug design, development and therapy dove...