Retroviral integration, the process of covalently inserting viral DNA into the host genome, is a point of no return in the replication cycle. Yet, strand transfer is intrinsically iso-energetic and it is not clear how efficient integration can be achieve
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Over the past few years, a variety of developments have been introduced to expand the utility ofλD for drug discovery, including an Adaptive Landscape Flattening (ALF) algorithm for automated bias determination41,43, a Potts model-based estimator for computing free energy differences and intersite...
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Hi, Wendy! For bills that fluctuate a little bit, I just put an estimation (on the high side), so we know around how much to expect, and then I write the actual amount in the tiny check box so we can keep track and know if our estimation is still on par. I hope this helps!
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