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The fetal fraction, or percentage of total cell-free DNA (cfDNA) in a sample derived from the fetus, can impact NIPT results and profitability.
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In one case there was a pregnancy with vanishing twin detected by ultrasound which may have contributed to the indeterminate sex result with the noninvasive cell-free prenatal test. In the non-PGT-A group, 27 pregnancies had positive prenatal-cfDNA screening results (1.5%, 27/1,769) (Table ...
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The results of both this review and meta-analysis and the analysis by Devaney et al.[11] show that the diagnostic test of fetal sex determination using cffDNA is expected to be close to 100%, it can be done early in pregnancy, and that the test itself carries no risk of miscarriage ...
This test encompasses the following three of the most frequent pathogenic genetic variations: aneuploidies, microdeletions and monogenic variants. The cfDNA screening results were compared to invasive prenatal or postnatal diagnostic test results for 1,090 qualified participants. The comprehensive cfDNA ...