Diagnostic and prognostic markers are necessary to help in patient diagnosis and the prediction of future clinical events or disease progression. As promising biomarkers of selected diseases, the free light chains (FLCs) κ and λ were considered. Measurements of FLCs are currently...
free light chainsFLC ratioplasmaproliferative diseaseprognostic factorQuantitation of monoclonal immunoglobulins and their fragments is used for monitoring the plasmaproliferative disease course and the effect of therapy. The aim of free light chains examination was to evaluate the significance of the FLC ...
How lab staff and the estimation of free light chains can combine to aid the diagnosis of light chain disease. 来自 Semantic Scholar 喜欢 0 阅读量: 20 作者: DAVID SINCLAIR,LAURA WAINWRIGHT 摘要: The diagnosis and monitoring of free light chain abnormalities and disease has always been a ...
Related to light chain:Myosin light chain kinase n. Either of the two smaller polypeptide chains in an immunoglobulin molecule, consisting of an antigen-binding portion with a variable amino acid sequence and a constant region that occurs in two different forms in humans. ...
Free light chains in patients with acute heart failure secondary to atherosclerotic coronary artery disease. Free light chains in patients with acute heart failure secondary to atherosclerotic coronary artery disease. Shantsila E,Wrigley B,Lip G Y. The American ... E Shantsila,JM Faint,B Wrigley...
Free Light Chains (FLCs) are immunoglobulin light chains which are circulating in serum in a free state (unbound). There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosi...
Also Known As: Free Light Chains, SFLC, FLC, Kappa and Lambda Free Light Chains, Quantitative Serum Free Light Chains with Ratio Board Approved At a Glance Why Get Tested? To help detect, diagnose, and monitor plasma cell disorders (dyscrasias) such as multiple myeloma, primary amyloidosis,...
Autoimmune diseaseArthritisInflammation, free light chains, urineThe risk of infection in patients with rheumatic diseases is elevated, but a clear marker to differentiate the cause of the systemic inflammation is missing. We assessed the ability urinary immunoglobulin free light chains (FLCs) to ...
Free-light-chain concentrations were measured in healthy individuals (to determine biological variation), patients with monoclonal gammopathy of undetermined significance, myeloma patients after autologous stem cell transplants, and patients with renal disease.Analytical imprecision (CV) was 6-11% for ...
Conclusion. IFE is more sensitive than HLC and FLC assays in detecting residual disease. CR with normalization of HLC and FLC ratios have impact on PFS. 展开 关键词: Heavy/light chain assay free light chains multiple myeloma minimal residual disease remission ...