Quantitation of free kappa light chains in serum and urine using a monoclonal antibody based inhibition enzyme-linked immunoassay. J Immunol Methods. 1987 May 4; 99 (1):141–147.Axiak SM, Krishnamoorthy L,Guinan J, et al. Quantitation of free kappa light chains in serum and urine using a ...
serum free light chainsserum protein electrophoresisFor many years, Bence Jones proteinuria has been an important diagnostic marker for multiple myeloma. Relatively new serum tests for free kappa and free lambda light chains of immunoglobulins reflect the production of free light chains more accurately ...
Introduction Kappa and lambda free light chains (FLC) are a side product of immunoglobulin synthesis. They are small molecular weight proteins and are present in serum of healthy people. They are increased in various diseases with enhanced immunoglobulin production. Like other small molecular we...
Serum kappa free light chain (FLC) was extremely elevated, >33,000 mg/dL. Treatment with therapeutic plasma exchange (TPE) started day 2 for biopsy-confirmed cast nephropathy. Bortezomib-containing chemotherapy was initiated on day 5, and hemodialysis for tumor lysis syndrome on day 7. TPE ...
Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem. 2002;48(9):1437–44. CAS PubMed Google Scholar Waldmann TA, Strober W, Mogielnicki RP. The renal handling of ...
Free Light Chains (FLCs) are immunoglobulin light chains which are circulating in serum in a free state (unbound). There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosi...
The paper deals with examination of free kappa light chains (FKLC) in the cerebrospinal fluid and serum of patients with multiple sclerosis (MS). The patient group included 84 women (mean age 34.03 ± 10.33 years) and 24 men (mean age 33.81 ± 10.61 years). The average disease duration ...
Also Known As: Free Light Chains, SFLC, FLC, Kappa and Lambda Free Light Chains, Quantitative Serum Free Light Chains with Ratio Board Approved At a Glance Why Get Tested? To help detect, diagnose, and monitor plasma cell disorders (dyscrasias) such as multiple myeloma, primary amyloidosis,...
The normal range for free lambda chains in serum was found to be 0.4–4.2 mg/1 and for free kappa chains it was 1.6–15.2 mg/1. At diagnosis the serum of most patients with multiple myeloma contained increased levels of the malignant free light chain and in some cases there was also ...
Kappa free light chains (KFLC) index has been described as a reliable marker of intrathecal immunoglobulin G (IgG) synthesis in multiple sclerosis (MS), resulting even more accurate than IgG index to discriminate MS from other neurological diseases1,2,3. Immunoglobulin free light chains (FLC),...