The addition of SPEP to total kappa/lambda assays improved the performance to detect abnormalities, but even combined they were neither as sensitive, specific or accurate as the Freelite assay. Given the limitations of the total light chain assays identified in our stu...
Free kappa and lambda light chains are antibody fragments secreted by plasma cells in the bone marrow. Plasma cells secrete either kappa or lambda free light chains into the bloodstream as a by-product of antibody production. In myeloma the proliferation of malignant plasma cells leads to an incr...
The paper deals with examination of free kappa light chains (FKLC) in the cerebrospinal fluid and serum of patients with multiple sclerosis (MS). The patient group included 84 women (mean age 34.03 ± 10.33 years) and 24 men (mean age 33.81 ± 10.61 years). The average disease duration ...
Initially, serum free light chain testing is ordered along with a serum protein electrophoresis test to detect abnormal monoclonal protein (M-protein) production and to calculate a kappa/lambda free light chain ratio. If the protein electrophoresis test is abnormal, then an immunofixation electrophores...
Ratio FLC value (kappa FLC/lambda FLC) compared to reference ranges may indicate presence of plasma cell disorders disease like Multiple Myeloma or AL amyloidosis in a patient. Nephelometric and turbidimetric based assays have been shown to overestimate the sFLC levels that are not always consistent...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook KAP (redirected fromKAPS) Acronyms KAP Kernel Andorra Prolog. The predecessor ofAKL. ["Kernel Andorra Prolog and its Computation Model", S. Haridi <seif@sics.se> et al, in Logic Programming: Proc 7th Intl...
The free light chain (FLC) assay does quantify concentrations of free kappa and lambda immunoglobulin light chains in serum. The potential use of this diagnostic test for patients diagnosed with plasma cell dyscrasias includes, amongst others, primary diagnosis, prognosis, detection of relapse and mon...
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A. et al. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: Relative sensitivity for detection of monoclonal light chains. Clin Chem. 48(9), 1437–1444 (2002). Article CAS Google Scholar Download references Funding This work was supported...
kappa- the 10th letter of the Greek alphabet lambda- the 11th letter of the Greek alphabet mu- the 12th letter of the Greek alphabet nu- the 13th letter of the Greek alphabet xi- the 14th letter of the Greek alphabet omicron- the 15th letter of the Greek alphabet ...