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Designing synthetic DNA and sequence manipulation for CF synthesis by adding regulatory elements plays a significant role in high-yield protein production. In eukaryotic CF systems, initiation factors (IFs) in particular limit the initiation of protein synthesis, thereby leading to low protein yields. ...
Our artificial chimera couples a protein segregation and unfolding process to a downstream proteolytic reaction, resulting in a semisynthetic prototype of the 26S proteasome: a self-compartmentalized and unfoldase-assisted protein degradation machine3. Through precise control of stoichiometry, spatial ...
原间隔邻近基序(PAM:protospacer adjacent motif),CRISPR关联抗病毒复合物(Cascade:CRISPR-associated complex for antiviral defense),trans-activating CRISPR RNA (tracrRNA),多核苷酸磷酸化酶(PNPase:polynucleotide phosphorylase)。Cse1为Ecoli亚类Cas;Csy1-4为Ypest亚类Cas;Csn2为Nmeni亚类Cas;Csm3为Mtube亚类Ca...
Q9N0V4 15 Glutathione S-transferase Mu 1 GSTM1 0.035 8.081 Glutathione tranferase activity, cellular detoxification, cellular growth and proliferation Q2KIR8 11 L-threonine 3-dehydrogenase, TDH 0.010 5.275 Co-enzyme binding, oxidoreductase E1BHZ6 19 Glutaminase 2 GLS2 0.007 4.695 Citrulline biosynthes...
coli CFPS through recreation of the biosynthetic pathway and used to convert apo [FeFe] hydrogenase to active protein [132]. 3.2.8. Miscellaneous Applications CFPS has also been used for a number of miscellaneous applications, including studies of translational machinery, genetic circuits, metabolic ...
Aselizumab, Atezolizumab, Atinumab, Atlizumab, Atorolimumab, Avelumab, Bapineuzumab, Basiliximab, Bavituximab, Bectumomab, Begelomab, Belimumab, Benralizumab, Bertilimumab, Besilesomaab, Bevacizumab, Bezlotoxumab, Biciromab, Bimagrumab, Bimekizumab, Bivatuzumab mertansine, Bleselumab,...
Geissler et la., Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid hehydrogenase 3. Nat. Genetics, 7: 34-9 (1994). Gencic et. al., Conservative amino acid substitution in the myelin proteolipid protein of Jimpymsd mice. J. Neurosci., 10(1):117-24 (1990)...
For example, miR-22 promotes breast cancer growth by suppressing acetylase TIP60, an epigenetic modifier and EMT promoter [37]. Furthermore, miR-22 is involved in hepatocellular carcinoma, which induces cell proliferation, migration, and invasion by downregulating CD147 [38]. Moreover, miR-22 ...
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