Full size image Next, we applied PIP-seq to study MPAL, a high-risk disease characterized by multiple hematopoietic lineages38,39. Recurrence and changes in immunophenotype with chemotherapy are typically monitored using flow cytometry of surface markers during diagnosis, treatment and relapse, but th...
on a wide variety of topics--training, safety, risk communication, and more. We figured you might appreciate it if we created one blog post that includes links to all those different free downloads we offer. And that's what this post is. Please note: Although there's no financi...
Considering the molecular heterogeneity of AML, MRD analysis based on mutation biomarkers in bone marrow DNA could provideactionabilityto guide treatment decision as a complementary method for MFC and morphology-based assessment of remission. The sensitivity and cost for NGS MRD analysis are dependent ...
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最早的AML模型是在斑马鱼胚胎中短暂表达人融合癌基因,然而这些模型均存在早期致死现象,无法在成体期进行研究[59,60]。第一个成功的非胚胎致死AML模型是用spi1启动子驱动MYST3-NCOA2融合基因表达,该模型中髓系前体细胞广泛侵袭斑马鱼肾脏,然而AML发病率低、潜伏期长[61]。在时间上控制致癌基因的表达可以有效解决胚胎...
近年来,机器学习为解决CRISPR/Cas9系统所面临的问题提供了新思路,基于机器学习的CRISPR/Cas9系统已逐渐成为研究热点。本文阐述了CRISPR/Cas9的作用机理,总结了现阶段该技术面临的基因组编辑效率低、存在潜在的脱靶效应、前间区序列邻近基序(PAM)限制识别序列等问题,最后对机器学习应用于优化设计高效向导RNA (sgRNA)序列、...
For verifying assay perfor- mance, tumour tissue DNA as positive control template (PTC) and non-template control (NTC) containing nuclease free water instead of cell-free DNA template, were analysed in triplicates. 2.12. Plasma Droplet Digital PCR Data Analysis The ddPCR data analysis was ...