Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons. Mol Neurodegener. 2012; 7 :51. doi: 10.1186/1750-1326-7-51. [ Cross Ref ]Franco C, Fernández S, Torres-Alemán I: Frataxin deficiency unveils cell-context dependent actions of insulin-...
Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from Thermus thermophilusTHERMUS thermophilusFRATAXINFRIEDREICH'S ataxiaNUCLEAR magnetic resonanceMOLECULAR dynamicsNqo15 is a subunit of respiratory complex I of the bacterium Thermus ...
We conclude that the primary pathological mechanism underlying the I151F mutation is frataxin deficiency, like in patients carrying GAA expansions. Therefore, patients carrying the I154F mutation would benefit from frataxin replacement therapies. Furthermore, our results also show that the FXN I151F...