The exons of FRAS1(Fraser extracellular matrix complex subunit 1), FREM1(FRAS1 related extracellular matrixprotein 1) and FREM2 gene mutation were screened by targeted gene capture sequencing and the mutations detected wereconfirmed by Sanger sequencing. Demographic and baseline clinical data were ...
The mutants of the first class are characterized by defects in embryonic fin morphogenesis, which are due to mutations in a Laminin subunit or an Integrin alpha receptor, respectively. The mutants of the second class display characteristic blistering underneath the basement membrane of the fin ...