amino acids. Depending upon the location of the mutation, such proteins may be wholly new or non-usable. Frameshift mutation can also result in the stop codon. This occurrence of thepremature stop codonon mRNA will terminate the translation process, thereby, resulting in a short-lengthpolypeptide...
Define frameshift mutation. frameshift mutation synonyms, frameshift mutation pronunciation, frameshift mutation translation, English dictionary definition of frameshift mutation. n. A mutation in a DNA chain that occurs when the number of nucleotides in
During a frameshift mutation, the nucleotide is inserted or deleted rather than replaced. A frameshift mutation results in change once the codons are read after mutation to produce different amino acids. There are cases where a stop codon might be produced during a frameshift mutation which results...
ReFrame is not only able to quantify mutation frequency but also to distinguish indel mutation types, which is crucial for the prediction of the frame of the resulting frameshift peptides. As the translation of nucleotide into amino acid sequences is based on three base codons, every mutation in...
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia. Breast Cancer Res. 2014;16(6):3419. Article PubMed PubMed Central Google Scholar Brnich SE, Abou Tayoun AN, Couch FJ...