Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells. Neural and oligodendrocyte precursor cells (NPCs and OPCs) in the subventricular zone (SVZ) of the brain contribute to oligodendrogenesis throug...
2021,Brain Research Bulletin ChaoWang, ...YanGu 3.1Chemokines, cytokines and neurotrophic factors Similar to peripheral immune cells,microgliaare responsive to many chemotactic agents (Tay et al., 2019).Fractalkine(also known as CX3CL1) is a neuronal chemokine. Single-cellRNA sequencingreveals that...
Introduction A diet high in saturated fat is well known to affect neuronal function and contribute to cognitive decline in experimental animals and humans. Fractalkine released from neurons acts on its receptor, CX3C chemokine receptor 1 (CX3CR1), in the microglia to regulate several brain ...
9.Ji JF, He BP, Dheen ST, Tay SS. Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury.Stem Cells. 2004;22:415-427.[PubMed][DOI] ...
Mouse and human fractalkine share 67% amino acid identity. Murine fractalkine acts on human cells1. Sources Fractalkine is produced by microglia, activated endothelial cells and neurons, and mRNA is expressed in brain, kidney, lung and heart1–3. Bioassays Chemotaxis or adhesion of lymphocytes. Ph...
(TLR4) signaling and endoplasmic reticulum stress. Microglia cells, which are the cellular components of the innate immune system in the brain, are expected to play a role in the early activation of diet-induced hypothalamic inflammation. Here, we use bone marrow transplants to generate mice ...
(A2AR) activity Maria Scianni1, Letizia Antonilli1, Giuseppina Chece1, Gloria Cristalli2, Maria Amalia Di Castro1, Cristina Limatola1,3*† and Laura Maggi1† Abstract Background: N-Methyl-D-aspartate receptors (NMDARs) play fundamental roles in basic brain functions such as excitatory ...
soluble CX3CL1 and CD8+ T cell CX3CR1 are overexpressed and appear to contribute to pathogenesis. In the brain, CX3CL1/CX3CR1 interaction protects against microglial neurotoxicity. CX3CL1 also contributes to wound healing by recruiting macrophages, and to bone resorption by recruiting and med...
(LPS).In vivo neutralization of endogenous brain fractalkine signal pathway increases inflammatory cytokines secretion and neuronal cell death induced by LPS.Fractalkine may achieve its neuroprotective property through influencing expression of pro-apoptotic and anti-apoptotic proteins,intracellular Ca2+ level ...
Fractalkine (CX3CL1) and brain inflammation: Implications for HIV-1-associated dementia Leukocyte migration and activation play an important role in immune surveillance and the pathogenesis of a variety of neurodegenerative disorders, includin... R Cotter,C Williams,L Ryan,... - 《Journal of Neuro...