作者进一步通过Foxp3、IL2rα、Ctla4序列CpG甲基化程度进行分析, exFoxp3 T细胞中Foxp3序列大部分被甲基化,Il2ra部分被甲基化(图2e)。这一结果与已知的tTreg细胞特征有所不同。另外,基因表达分析发现exFoxp3 TH17细胞高表达优先在pTreg细胞表达的分子Cxcr5、Ccr8、Rora、Rorc(更多数据请查阅原文补充材料);文中结合...
On the contrary, Helios~-CCR8~-Treg cells have impaired suppressive activity, and elevated expression of pro~-inflammatory cytokines. More advanced grades of PDAC have predominantly Helios~+CCR8~+Treg cells and few Helios~-CCR8~-Treg cells both in tumors and TDLNs that suggests poor prognosis...
作者进一步通过Foxp3、IL2rα、Ctla4序列CpG甲基化程度进行分析, exFoxp3 T细胞中Foxp3序列大部分被甲基化,Il2ra部分被甲基化(图2e)。这一结果与已知的tTreg细胞特征有所不同。另外,基因表达分析发现exFoxp3 TH17细胞高表达优先在pTreg细胞表达的分子Cxcr5...
这一结果与已知的tTreg细胞特征有所不同。另外,基因表达分析发现exFoxp3 TH17细胞高表达优先在pTreg细胞表达的分子Cxcr5、Ccr8、Rora、Rorc(更多数据请查阅原文补充材料);文中结合更多实验表明ex Foxp3 TH17细胞很可能来源于pTreg细胞亚群。 Figure 2.Localization, marker gene expression and DNA methylation status ...
CCR8+FOXp3+Tregcells as master drivers of immune regulation The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than... Yiftah,Barsheshet,Gizi,... - 《Proceedings of the National Academy of...
CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J. Immunol. 177, 6940–6951 (2006). Article CAS PubMed Google Scholar Guo, Z. et al. CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory ...
(B) Single-cell mRNA expression of Treg markers (FOXP3, IL2RA, CTLA4, Helios, LSGALS, and IKZF4), chemokine receptor CCR8 and the housekeeping gene B2M were plotted for RA−DR− and RA−DR+ Tregs and Tconvs. One of 3 analyses of 3 different patients is shown. The low number ...
LAG3,CCR8,UBD, LGALS3等基因mRNA表达.结果 (1)急性期KD患儿CD4+T细胞Foxp3基因启动子CpG岛非甲基化水平明显低于同年龄对照组(P<0.01),经IVIG治疗后明显升高 ... 王国兵,李成荣,杨军,... - 《中华微生物学和免疫学杂志》 被引量: 2发表: 2010年 Regulation of antitumour CD8 T-cell immunity and chec...
这一结果与已知的tTreg细胞特征有所不同。另外,基因表达分析发现exFoxp3 TH17细胞高表达优先在pTreg细胞表达的分子Cxcr5、Ccr8、Rora、Rorc(更多数据请查阅原文补充材料);文中结合更多实验表明ex Foxp3 TH17细胞很可能来源于pTreg细胞亚群。 Figure 2.Localization, marker geneexpression and DNA methylation status ...
More advanced grades of PDAC have predominantly Helios^+CCR8^+Treg cells and few Helios^-CCR8^-Treg cells both in tumors and TDLNs that suggests poor prognosis. These data could help further define the role of Treg cells and their functional role in tumors and TDLNs.科学通报(英文版)Gang...