Short report:FOXN1 mutation abrogates prenatal T-cell development in humansBackground The transcription factor FOXN1 is implicated in the differentiation of thymic and skin epithelial cells, and alterations in it are responsible for the Nude/SCID phenotype. During a genetic counselling programme offered...
[2]Adriani M,Martinez-Mir A,Fusco F,et al. Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population[J]. Ann Hum Genet,2004,68:265-...
A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008] Size:50ul Concentration:1mg/ml Applications:WB(1:500-2000)...
resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin diso...
A point mutation in this genome element results in a defect in b5t expression and CD8 þ T-cell production in mice. The results reveal a Foxn1-b5t transcriptional axis that governs CD8 þ T-cell production in the thymus. 1 Division of Experimental Immunology, Institute of Advanced ...
Point Mutation Conditional Point Mutation Humanization Targeted Conditional Overexpression Random Transgene Surgery & Preconditioning Surgery Preconditioning Therapeutic Area Oncology Syngeneic Models GEMM-Derived Allografts Humanized Mice CDX Models PDX Models Humanized Drug Target IO Mice ...
** = statistically very significant observed postnatal FoxN1 gain-of-function mutation-induced newborn lethal phenotype, and the mice have a normal lifespan. We found, by observing GFP expression in juvenile (2 weeks) thymuses, that Cre-recombinase leakage in K5CreERT was not as strong as ...
A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. 分子量 69 kDa 基因ID 8456 NCBI登录号 NM_003593, NP_003584 UniProt O15353 研究领域 ...
Changing in lipid profile induced by the mutation of Foxn1 gene: A lipidomic analysis of Nude mice skin[J]. Biochimie, 2015, 118:234-243. [15]Heidenreich B, Denisova E, Rachakonda S, et al. Gene-tic alterations in seborrheic keratoses[J]. Oncotarget, 2017, 8: 36639-36649. [16]...
resulting in a severely compromised immune system This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder...