此时,FOXD1 (forkhead box D1, FOXD1),即FOXD1- as1的同源意义转录本引起了作者的注意,因为它已被证实在胃癌组织中上调,并被确认为多种癌症的致癌基因。有趣的是,作者观察到沉默的FOXD1- as1在蛋白水平上明显抑制FOXD1的...
FOXD1-AS1miR-369-3poral squamous cell carcinomaRecently, increasing attention has been concentrated on decrypting the potential of long non-coding RNAs (lncRNAs) in influencing the progression of human tumors, oral squamous cell carcinoma (OSCC) included. The role of a novel lncRNA, forkhead box...
本发明公开了FOXD1AS1的抑制剂在制备治疗鼻咽癌药物中的应用.本发明研究表明,FOXD1AS1在NPC细胞及组织中明显上调并与患者预后呈负相关,敲除和上调FOXD1AS1的表达分别能增强或抑制体外和体内NPC细胞的增殖,并分别抑制或促进体外和体内细胞凋亡;此外,我们证明FOXD1AS1的上调会增加FOXD1mRNA及蛋白的稳定性,FOXD1作为...
However, the role of FOXD1-AS1 in the differentiation and progression of glioma is not well known.Expression profile chip and qPCR were used to screen and identify FOXD1-AS1. Glioma cells were transfected with siRNA or eukaryotic expression vector to observe FOXD1-AS1 function in vitro and...
本发明公开了KTN1AS1的抑制剂在制备治疗膀胱癌药物中的应用.本发明研究表明,KTN1AS1在BUC细胞及组织中明显上调并与患者预后呈负相关,敲除和上调KTN1AS1的表达分别能增强或抑制体外和体内BUC细胞的增殖,并分别抑制或促进体外和体内细胞凋亡;此外,我们证明上调的KTN1AS1能募集EP300到KTN1启动子,激活KTN1表达,并通过...
Long non‐coding RNAFOXD1‐AS1 modulated CTCs epithelial‐mesenchymal transition and immune escape in hepatocellular carcinoma in vitro by sponging miR‐615‐3pdoi:10.1002/cnr2.2050Guo, Bao‐lingZheng, Qiu‐xiangJiang, Yun‐shanZhan, YingHuang, Wen‐jin...