Aberrant expression of the Forkhead box transcription factor, FOXQ1, is a prevalent mechanism of epithelial-mesenchymal transition (EMT) and metastasis in multiple carcinoma types. However, it remains unknown how FOXQ1 regulates gene expression. Here, we report that FOXQ1 initiates EMT by recruiting...
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are master pioneer transcription factors that play a crucial role in loosening the compact chromatin structure and facilitating the binding of other transcription factors, thus regulating tissue-specific gene expression14,15. In prostate adenocarcinoma, FOXA1 acts as a critical pioneer factor for AR, a...
We confirmed that the known node, AME and DE markers described above (Foxa1, T, Foxd4, Sox17, Cer1; Table 1 and Additional File 1) had reduced levels in the Foxa2 mutant embryo. Reduction of these known markers provided evidence that our microarray-based screen could detect changes in ...
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possibly indicating defects in gastrulation movement. Thefoxa2stains also suggested thatFHD-GFPhas mild effects on endoderm formation (arrowheads in Fig.4e–h). Further analyses of the endoderm markersox17confirmed a slightly reduced amount of endoderm cells, and in addition, they revealed strongly ...
The PCR products were treated with Dpn1 endonuclease (New England BioLabs, Hitchin, Hertfordshire, UK) to digest the methylated parental DNA template. Luciferase reporter vectors containing IFN-stimulated response element (ISRE) and IFN-gamma activation site (GAS) response element were purchased from ...