Our findings can help to better understand the balance between the two selective pressures in commercial goat breeds providing new insights on the molecular mechanisms of adaptation.Similar content being viewed by others Characterization of heterozygosity-rich regions in Italian and worldwide goat breeds ...
Genome-enabled biotechnologies have the potential to accelerate breeding efforts in long-lived perennial crop species. Despite the transformative potential of molecular tools in pecan and other outcrossing tree species, highly heterozygous genomes, significant presence–absence gene content variation, and hist...
2,3,4] and the blood-cerebrospinal fluid barrier (BCSFB) [5,6], play a crucial role in controlling the internal environment of the brain. These barriers, comprised of endothelial cells, pericytes, astrocytes, and other cell types, act as selective filters, controlling the movement of substanc...
modifications in the photosynthetic apparatus and constitute one of the protective mechanisms of plant survival16. Stressful environmental conditions also strongly influence the levels and composition of bioactive compounds, including phenolic compounds, which is of pivotal importance in the case of species ...
based on the absorption derived from two states of retinal chromophore in the opsin molecules, deprotonated and protonated states of the retinylidene Schiff base, which are basic spectral tuning mechanisms for UV- and visible light-sensitivities of opsin-based pigments, respectively (SeeDiscussionsection...
Additionally, we examined the downstream molecular mechanisms of SNHG4 through functional rescue experiments, providing insights into its potential regulatory impact on COPD progression. Materials and methods Clinical tissue specimens Forty non-smoking patients with COPD, 40 smoking patients with COPD, and...
An old and enduring notion in psychiatry is that the therapeutic and adverse effects of antipsychotic drugs frequently co-occur [32, 33], indicating that they work through more or less similar or overlapping mechanisms. This is true in the case of their antidopaminergic properties which produce ...
An old and enduring notion in psychiatry is that the therapeutic and adverse effects of antipsychotic drugs frequently co-occur [32, 33], indicating that they work through more or less similar or overlapping mechanisms. This is true in the case of their antidopaminergic properties which produce ...
In Arabidopsis, protein phosphatases play key roles in regulating cellular activities and often affect ROS homeostasis, especially in response to environmental stimuli15–17. There are two known glucan phosphatases in plants: STARCH EXCESS4 (SEX4) and LIKE SEX FOUR2 (LSF2). SEX4 is a major ...
Association of 4-week intermittent fasting from dawn to sunset with autophagy and oxidative stress parameters Autophagy appears to be one of the mechanisms of intermittent fasting in cancer prevention73. Downregulation of the hepatocystin encoded by PRKCSH results in dysfunctional glucosidase II, and th...