The enzymes were assumed to follow Michaelis–Menten kinetics, described with a k cat (k i f and k i r for forward and reverse, where i is the first letter of the enzyme) and K M (K i,j where i is the enzyme and j the metabolite). tHMGR was assumed to operate with an excess...
Below is an excerpt from his letter [84] (p. 76): Recently it occurred to me to determine the general properties of solids bounded by plane faces, because there is no doubt that general theorems should be found for them, just as for plane rectilinear figures, whose properties are: (1)...