Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development. CPT pharmacometrics Syst. Pharmacol. 2, e63 (2013). 9. Wagner, C. et al. Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Work...
Volume kinetics is an adaptation of pharmacokinetic theory that makes it possible to analyse and simulate the distribution and elimination of infusion fluids [29]. Applying this concept, it is possible, by simulation, to determine the infusion rate that is required to reach a predetermined plasma ...
In the last few years, 3D printing has emerged as a promising alternative for the fabrication of microfluidic devices, overcoming some of the limitations a
They proposed that hepatotoxic potency differences between BDCM and CHCl3 “may be due to pharmacokinetic dissimilarities such as greater metabolism of BDCM to reactive metabolites or more extensive partitioning of BDCM into kidneys and fat depots, resulting in prolonged target tissue exposure”. The ...
Current oral medications for type 2 diabetes target a single main physiological mechanism. They either activate or inhibit receptors to enhance insulin sensitivity, increase insulin secretion, inhibit glucose absorption, or inhibit glucose production. In