While validation of health economic decision models has always been considered important, many reviews of model-based cost-effectiveness studies report limitations regarding their validation. The current opinion paper discusses four aspects of current health economic decision modeling with relevance for ...
Together with our results, it remains unclear whether CSF t-tau and p-tau reflect similar or different aspects of neuronal injury. Higher levels of t- and p-tau might result from passive release into extracellular space due to neuronal death which increases with worse disease severity. However,...
During the COVID-19 pandemic, we focused on various aspects of COVID-19 pharmacotherapy and different therapeutic options, pharmacokinetic aspects of considered drugs, potential drug-drug interactions (PDDI) among anti-COVID-19 drugs with others, and adverse drug reactions (ADRs) managements in ou...
Because the UCR and NCVS programs have different purposes, use different methods, and focus on somewhat different aspects of crime, the complementary information they produce together provides a more comprehensive understanding of the nation’s crime problem than either could produce alone. … The ...
Women are more likely to suffer from Alzheimer's disease and osteoporosis, while men are more likely to develop cancer and Parkinson's disease [1,2]. Sex also has widespread effects in many other aspects, such as immune response [[3], [4], [5], [6], [7], [8]], emotion and ...
Metabolic syndrome has adversely impacted many aspects of society3. Importantly, metabolic syndrome is a significant risk factor for several common cancers (e.g., liver, colorectal, breast, endometrium, pancreas)4,5. Disrupted circadian clock rhythm has been recognized as one of the causes of ...
By 2050, the worldwide incidence of hip fracture in women is expected to increase by 310%, mainly due to the ageing of the worldwide population3. Bone remodeling is a continuous process between bone resorption (activity of osteoclasts (OCs)) and formation (activity of osteoblasts (OBs)). ...
The pedigree of a Yorkshire family afflicted with lattice dystrophy of the cornea is presented. Of the eight "certainly affected" members, seven were examined by the authors. Clinical aspects are described and details are given of the histopathology of a corneal disc. The pattern of inheritance ...
These aspects make it difficult to develop a suitable morcellation bag. Tissue and fluid spread during power morcellation is usually caused by the rotating blade. In-bag morcellation was expected to reduce the risk of tissue dissemination secondary to the morcellation process. However, retrieval of ...
Before the adjustment, the four scoring systems were all risk factors for 30-day mortality in intensive care patients with sepsis (allP < 0.001). Variables with aP-value of < 0.1 in univariate regression analysis (age, septic shock, coronary atherosclerotic heart disease, hypertension, ...