On the basis of the evaluation, the best batch F8 formulation demonstrated highest drug content and entrapment\nefficiency with average particle size of 0.004m. The saturation solubility studies show the solubility of the prepared nanosuspension\nhas increased as compared to the pure drug due to ...
The aim of the present research was to development of formulation & evaluation of Zidovudine oral Nanosuspension. Zidovudine is a potent in vitro inhibitor of human immune deficiency virus belongs to the category of anti-retro viral drug. Zidovudine has the short biological half life and poor ...
Formulation and evaluation of nanosuspension of albendazole for dissolution enhance- ment. Nanosci Nanotechnol Lett. 2013;5(9):1024–1029. doi:10.1166/ nnl.2013.1645. 24. Pandya VM, Patel JK, Patel DJ. Formulation and optimization of nanosuspensions for enhancing simvastatin dissolution using central...
The primary objective of the present research work was to develop nanoparticles incorporating (nanoparticulate) fast dissolving (orodispersible) film evincing enhanced solubility and bioavailability of nitrendipine (NIT). An antisolvent sonoprecipitation method was employed to produce the NIT nanosuspension (...
Nanosuspension of efavirenz for improved oral bioavailability: formulation optimization,in vitro, in situandin vivoevaluation to investigate its potential in enhancing the oral bioavailability of EFV.%Materials and methods: EFV NS was prepared using the media milling technique. The... GV Patel,VB Pate...
Development and in vivo/in vitro evaluation of novel herpetrione nanosuspension [J]. Int J Pharm, 2013, 441: 2 [26] Verma S, Gokhale R, Burgess DJ. A comparative study of topdown and bottom-up approaches for the preparation of micro/nanosuspensions [J]. Int J Pharm, 2009, 380: ...
Topical ketoprofen nanogel: artificial neural network optimization, clustered bootstrap validation, and in vivo activity evaluation based on longitudinal d... This work aimed at investigating the potential of solid lipid nanoparticles (SLN) as carriers for topical delivery of Ketoprofen (KP); evaluating...
The poor solubility of Form B resulted in a significant reduction in the oral exposure from a nanosuspension to a level that was insufficient for toxicological evaluation of compound1. Subsequent to the discovery of Form B, multiple form and formulation engineering strategies were evaluated for their...
Nanosuspension Nanosuspensions have emerged as an effective strategy for the delivery of hydrophobic drugs because of the unique versatility and advantages in formulation. AFA can be used to create nanosuspensions through the complete life cycle from discovery through first human trials. By enabling clos...
This study proposed to follow a screened sirolimus nanosuspension formulation [37] and develop ionic in situ gels with gellan gum. Given the ocular surface temperature of 34 °C and a pH range of 6.4–7.7, the gelling of ionic in situ gels was dependent on the ions in the solution, irresp...