Measurement of intestinal permeability either in vivo in human neonates or ex vivo in animal models consistently reveals a higher permeability in formula-fed compared with breast-fed neonates (11,13). In our experiment, NBW animal intestinal permeability was poorly affected by formula feeding. However...
Recently, integrative pharmacology has become a pivotal paradigm for the modernization of TCM and combinatorial drugs discovery, which is an interdisciplinary science for establishing the vitro/vivo correlation between absorption, distribution, metabolism, excretion and pharmacokinetic (ADME/PK) profiles of ...
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Herbal medicines usually contain a large group of chemical components, which may be transformed into more complex metabolites in vivo. In this study, we proposed a knowledge-transmitting strategy for metabolites identification of compound formulas. Gegen-Qinlian Decoction (GQD) is a classical formula...
Harpagide (P12) possesses anti-inflammatory activity in carrageenan-induced inflammation in vivo49. Angoroside C (P23) exhibits activity in the regulation of nitric oxide (NO) in LPS-stimulated macrophages50. Cinnamic acid (P28) reduces LPS-stimulated IL-6 production in macrophages. These 4 ...
Harpagide (P12) possesses anti-inflammatory activity in carrageenan-induced inflammation in vivo49. Angoroside C (P23) exhibits activity in the regulation of nitric oxide (NO) in LPS-stimulated macrophages50. Cinnamic acid (P28) reduces LPS-stimulated IL-6 production in macrophages. These 4 ...
The purpose of this study was to further investigate the therapeutic material basis and intervention mechanism of AESS formula in the treatment of AD, and to verify the mechanism through network pharmacology and pharmacological experiments in vivo. 2. Material and methods 2.1. Preparation of AESS ...
further investigations into the effect of alpha-tocopherol on bleeding in vivo have not duplicated these findings. A total of 42 healthy volunteers complied with a 2-week abstinence period from the use of anti-platelet agents followed by determination of baseline platelet aggregation properties and co...
(D) Real-time q-PCR results showing relative mRNA levels of LXRα, PPARα, PPARβ and ERα after in-vivo siRNA-mediated silencing for the indicated time points; results were expressed as fold change over control siRNA delivery (n = 3 animals per group). *p < 0.01 versus ...
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