Kathleen Fackelmann
Tony S. KorosiJudith K. MarquisElsevier Inc.Biological PsychiatrySiek GC, Kats LS, Fishman EB, Korosi TS, Maquis JK (1990) Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain. Biol Psychiatry 27: 573–580...
Iron accumulation in the brain is a phenomenon common to many neurodegenerative diseases, perhaps most notably Alzheimer's disease (AD). We present here magnetic analyses of post-mortem brain tissue of patients who had severe Alzheimer's disease, and compare the results with those from healthy ...
Biochemical and immunocytochemical analyses were performed to evaluate the composition of the amyloid beta protein (A beta) deposited in the brains of patients with Alzheimer's disease (AD). To quantitate all A beta s present, cerebral cortex was homogenized in 70% formic acid, and the supernatan...
We show that dGAE forms PHFs that share a macromolecular structure similar to those found in brain tissue. Thus, dGAEs may serve as a model system for studying core domain assembly and for screening for inhibitors of tau aggregation. Abbreviations AD, Alzheimer’s disease AFM, atomic force ...
Abnormally phosphorylated tau is present both in PHF and non-PHF forms in Alzheimer disease brain: E. Köpke, K. Iqbal and I. Grundke-Iqbal. Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd., Staten Island, NY, 10314, USA...
* & Michelle E. Ehrlich2,3,5,6,7,* The presenilin 1 (PSEN1) L271V mutation causes early-onset familial Alzheimer's disease by disrupting the alternative splicing of the PSEN1 gene, producing some transcripts harboring the L271V point mutation and other transcripts lacking exon 8 (PS1...
Plant natriuretic peptides (PNPs) are hormones that have been extracted from many different species, with theArabidopsis thalianaPNP (AtPNP-A) being the most studied among them. AtPNP-A is a signaling molecule that consists of 130 residues and is secreted into the apoplast, under conditions of...
In the last decade, high performance liquid chromatography (HPLC) has been widely used in the analysis of peptides in various fields of research and development, using different modes of separation. Nowadays, hydrophilic interaction liquid chromatography (HILIC) is ideal for the analysis of peptides...
The constituent paired helical filaments (PHFs) in neurofibrillary tangles are insoluble intracellular deposits central to the development of Alzheimer's disease (AD) and other tauopathies. Full-length tau requires the addition of anionic cofactors such as heparin to enhance assembly. We have shown ...