Four organic halides: 2-bromofluorene, 2-bromothiophene, chlorobenzene and chlorodiphenylmethane were selected for study in the light of their reputed poor performance in the Grignard reaction3. A quantitative estimate of the amount of Grignard reagent formed in each reaction was carried out by the ...
The first work undertaken was a calorimetric study of the formation and subsequent decomposition of a Grignard reagent. Open image in new window From (1) and (2), the heat of formation of the R I compound can be obtained: Open image in new window From Q f ( R I, g ) and the ...
situationafteralaterinitiationofthereaction. 3 Onproduction scale,engineersarefacedwithsignificantsafetychallenges. Recently,real-timeonlineanalyticalanalysiswithFTIRhas beenshowntoprovidevaluableinformationforasafe generationofaGrignardreagentonindustrialscale. 3 Itisknownthatundercompletelydryconditionsthe formationofthe...
Electron transfer at the solid liquid interface; new insights on the mechanism of formation of the grignard reagentMatricesModelingThe strong inhibiting effect of trace quantities of selected compounds on the reaction between ultra fine particles of magnesium and alkyl halides in THF strongly suggests ...
WALBORSKY H.Mechanism of Grignard reagent forma-tion.the surface nature of the reaction [J].Acc.Chem.Res.,1990,23(9):286-293.H. M. Walborsky.Mechanism of Grignard reagent formation. The surface nature of the reaction.Accounts of Chemical Research. 1990...
A general and reliable method for the activation of magnesium metal for the formation of various kinds of Grignard reagents has been developed. Utilizing diisobutylaluminum hydride (DIBAH) for the activation of the surface and drying of the reaction mixture the initiation of the Grignard reagent forma...
- 《European Journal of Organic Chemistry》 被引量: 15发表: 2009年 How To Prepare a Chiral Grignard Reagent: A Theoretical Proposal It is shown that two competitive pathways (T2 vs T4) exist for Grignard reagent formation. While the nonradical pathway T2 leads to retention of the config......
The first one is that alpha-halo esters can be treated with Zn to give enolates in a process called reductive formation of enolates . This is much like Grignard reagent formation. The resulting enolates can add to aldehydes and ketones in a reaction known as the Reformatsky reaction. Another...
A catalytic asymmetric conjugate addition reaction of organocopper reagents, generated from copper salt, a chiral phosphine, and Grignard reagent, with cyc... NK Tomioka - 《Tetrahedron》 被引量: 136发表: 1999年 Copper-Catalyzed Benzylic C−H Oxygenation under an Oxygen Atmosphere via N-H Imines...
Grignard reagent ob- tained was transferred to another 100 mL flask with a dropping funnel, and added dropwise into 45 mmol tetramethoxysilane in 24 mL dry THF in an ice bath. The product (4-methylphenyl)trimethoxysilane was directly distilled from the reaction mixture. The purity was checked ...