Bone marrow stromal cells represent a promising cell source for cell-based therapeutic and bone tissue-engineering applications, but are restricted by a lo... BA Byers,AJ García - 《Tissue Engineering Part A》 被引量: 155发表: 2004年 Effects of a miR-31,Runx2, andSatb2Regulatory Loop on...
18,19,20,21,22 The investigation of osteogenesis and the development of anabolic therapy are needed in the treatment of bone loss in IBDs.11,23 Osteoblastic bone formation is mediated by bone marrow mesenchymal stromal/stem cell (BMSCs), the common progenitor of osteoblasts and adipocytes.24 ...
The formation of a stable bone-implant interface is a prerequisite for the long-term success of any load-bearing implant1,2,3. Surface characteristics of the implant material, such as its chemical composition, morphology, and surface energy, all play a crucial role in successfully integrating the...
Bone marrow cells were collected by washing the femurs and tibias of WT and Trem2−/− mice with PBS. After the red blood cells were lysed, the cell suspension was filtered through a 70-µm sieve. The cells were cultured in DMEM supplemented with murine recombinant M-CSF (40 ng/mL...
The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and over-exuberant osteogenesis results in heterotopic ossification (HO) of soft tissues. RUNX2 is essential for tuning this ...
Burger, E. H., J. W. M. Van der Meer, J. S. Van de Gevel, J. C. Gribnau, C. W. Thesingh and R. Van Furth. 1982. In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes. J. Exp. Med. 156:1604. ...
Acute thrombosis is a crucial cause of bioresorbable vascular graft (BVG) failure. Bone marrow-derived mononuclear cell (BM-MNC)-seeded BVGs demonstrated high graft patency, however, the effect of seeded BM-MNCs against thrombosis remains to be elucidated. Thus, we evaluated an antithrombotic effec...
Currently, the main difficulty in the treatment of AS is its unclear pathogenesis, especially the unclear relationship between inflammation and pathological ossification. Human mesenchymal stem cells (hMSCs) have essential functions in both bone metabolism and immune homeostasis due to their strong immunore...
Since a long-term blockade of bone remodelling may have adverse effects on skeletal integrity, one of the major goals of skeletal research is to identify novel target proteins for osteoanabolic medication. One of the hormones considered to influence bone remodelling is calcitonin (CT), which was ...
20 In vitro studies also found that metformin had direct osteogenic effects on osteoblasts and increased osteogenic induction of bone marrow progenitor cells.21,22 However, in vivo studies investigating the effects of metformin on nondiabetic bone repair are extremely limited, and the results are ...