FOXO proteins, also known as Forkhead box O proteins, are a group of transcription factors involved in a variety of cellular functions, such as cell survival, metabolism, cell cycle regulation, and DNA repair (Huang and Tindall2007; Rodriguez-Colman et al.2023; Webb and Brunet2014). They hav...
Forkhead box proteins: tuning forks for transcriptional harmony. Nature reviews Cancer. 2013; 13 :482–495.Lam EW-F, Brosens JJ, Gomes AR, Koo C-Y (2013) Forkhead box proteins: tuning forks for transcriptional harmony . Nat Rev Cancer 13 : 482–495...
Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes. As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression. Here we discuss ...
Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and env...
The Forkhead box (FOX) proteins are an extensive family of transcription factors, which share homology in the winged helix/Forkhead DNA binding domain. Mutations of the FOX genes elicit pronounced defects on cellular proliferation, differentiation and metabolic homeostasis, leading to developmental abno...
The dominant role of Forkhead box proteins in cancer. Int J Mol Sci. 2018;19. Mukherjee A, Hollern DP, Williams OG, Rayburn TS, Byrd WA, Yates C, et al. A review of FOXI3 regulation of development and possible roles in cancer progression and metastasis. Front Cell Dev Biol. 2018;6:...
Genetic and biochemical data suggest a central role in embryonic development for forkhead proteins. 分子量 39 kDa 基因ID 668 NCBI登录号 NP_075555, NM_023067 UniProt P58012 研究领域 Chromatin and Nuclear Signaling, Transcription Factors 使用细节 Forkhead Box L2 (FOXL2) (N-Term) 抗体 ...
In comparison with ENCODE, we found 7,332 (∼2.1%) specific open chromatin peaks in HCASMCs, and we showed that these peaks are enriched with binding motifs for Forkhead box family proteins, which are known to regulate cell-type-specific gene expression.60 FOXP1 in particular has been show...
Epirubicin hydrochloride 抑制 DNA 和 RNA 合成。Epirubicin hydrochloride 是一种 Forkhead box 蛋白 p3 (Foxp3) 抑制剂,可抑制调节性 T 细胞活性。Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride) 是阿霉素的半合成的 L-阿拉伯糖衍生物,能够抑制 Topoisomerase,起到抗肿瘤的作用。Epirubicin hydrochloride ...
The dominant role of Forkhead box proteins in cancer. Int J Mol Sci. 2018;19. Mukherjee A, Hollern DP, Williams OG, Rayburn TS, Byrd WA, Yates C, et al. A review of FOXI3 regulation of development and possible roles in cancer progression and metastasis. Front Cell Dev Biol. 2018;6:...