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While intramolecular interactions within the drug molecule are the primary factor in determining the lowest energy conformation of the unbound drug, intermolecular interactions with the receptor also have a significant effect on conformation. If the bound conformation of a flexible molecule is also ...
Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proc. Natl Acad. Sci. USA 117, 25486–25493 (2020). Article ADS CAS PubMed PubMed Central Google Scholar Biebricher, A. S. et al. PICH: a DNA translocase ...
Transcription-factor-mediated protein–DNA condensation represents a possible mechanism by which transcription factors coordinate enhancer–promoter contacts in transcriptional hubs12. In this context, protein–DNA condensates could act as scaffolds, pulling co-factors into the droplet (Fig.4d). Our theoret...
Heat is a major factor in these forcing functions and it is generated during clutch slip as localised heat, particularly if the first gear ratio is unsuited for the vehicle and greater slip energy is required for pull away. Additionally, one would be concerned with heat migration from the engi...
16 Since June 2017, ongoing surveillance through article alerts and targeted searches of journals with a high impact factor and journals relevant to the topic was conducted to identify major studies published in the interim that may affect the conclusions or understanding of the evidence and ...
White-coat hypertension is a risk factor for cardiovascular diseases and total mortality. J Hypertens. 2017;35(4):677-688. doi:10.1097/HJH.0000000000001226PubMedGoogle ScholarCrossref 113. Pierdomenico SD, Cuccurullo F. Prognostic value of white-coat and masked hypertension diagnosed ...
Holbrook JA, Tsodikov OV, Saecker RM, Record MT: Specific and non-specific interactions of integration host factor with DNA: thermodynamic evidence for disruption of multiple IHF surface salt-bridges coupled to DNA binding. J Mol Biol 2001, 310(2):379–401. 10.1006/jmbi.2001.4768 Article CAS...
As a result, on the nanoparticle deposited surface, the surface tension force was magnified by a factor of 1.83. They proposed that surface tension force stabilized the evaporating meniscus, which favored the delayed CHF. For vertical orientation, Park et al. [45] observed 40% in CHF of ...
This unexpected negative correlation between feed rate and particle size is probably caused by high tool wear compared to feed per tooth, and it requires further investigation, as particle size, especially particulate matter, is a crucial factor regarding workplace safety. With respect to tool wear...