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Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this
Does the effectiveness of PSA-based screening vary by subpopulation or risk factor (eg, age, race/ethnicity, family history, or clinical risk assessment)? Three fair-quality RCTs (n = 647 906) assessed the effect of PSA screening on prostate cancer morbidity and mortality and all-cause...
Prostate-Specific Antigen–Based Screening for Prostate Cancer: A Systematic Evidence Review for the US Preventive Services Task Force: Evidence Synthesis No. 154. Rockville, MD: Agency for Healthcare Research and Quality; 2018. AHRQ publication 17-05229-EF-1. 4. Fenton JJ, Weyrich MS, Durbin ...
Transforming growth factor-β2 (TGF-β2) is secreted from bone marrow-derived cells and thus is relatively abundant. TGF-β2 binds to its receptors, TGF-β receptor-I (TGF-β-RI) and TGF-β-RIII, on cancer cell membranes and induces p38high/ERKlow signaling12. The subsequent activation...
A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) Developed in Collaboration With the American Society of Echocardiography, American ...
I’ve spent 20 minutes looking for her posts, but can’t find them, thought it might help to “chat” to someone who was in the same position, from memory, her sister and mother both died from ovarian cancer before 60, not sure if the BRCA gene was a factor in her case. It’s ...
These observations further substantiated prior suggestions that the high torsional rigidity of the Snf7 filaments is the driving factor for membrane curvature sensing and adaptation (45, 89). Another step forward was the design of soft sample supports. Using a soft PDMS cushion underneath the SLB,...