Learn about potential drug interactions you may be exposed to. Drug interactions can occur with prescription drugs, OTC medications, grapefruit and other foods, vitamins, herbs, supplements, and even laboratory tests.
For instance, cytochrome activity has been shown to decrease in older animals for some drugs such as acetaminophen [36] and isoniazid [37]. Several experimental approaches have been recommended to detect differences, ranging from an assessment of an overall measure of response by disaggregating small...
Isoniazid: Possible increased plasma carbamazepine concentrations Rifampin: Possible decreased plasma carbamazepine concentrations May increase isoniazid-induced hepatotoxicity Closely monitor plasma concentrations of carbamazepine and adjust dosage accordingly Antipsychotic agents (e.g., aripiprazole, clozapine, haloper...
Isoniazid Possible increased risk of hepatotoxicity Limit acetaminophen self-medication Phenothiazines Possible increased risk of severe hypothermia Acetaminophen drug interactions (more detail)Acetaminophen PharmacokineticsAbsorptionBioavailabilityWell absorbed following oral administration, with peak plasma concentrati...
14 In another recent study, once-daily dolutegravir-based ART and 3HP were initiated simultaneously in persons who required preventive therapy for tuberculosis, with similar results.15 In a pharmacokinetic study of daily isoniazid and rifapentine given for 1 month (1HP) for tuberculosis preventive...
Private sectors do not have much interest in stock because these drugs are dispensed free of charge and their demand is low. When they disregard isoniazid stocking, such lack of interest was assured. In addition, the prescriber’s desire for other alternatives, the negative thinking relating to ...
The objective of this study is to evaluate the safety, efficacy, and appropriate dosing of a 4-month regimen of QBS in combination with delamanid and bedaquiline in participants with drug-susceptible pulmonary TB in comparison with the 6-month standard treatment (i.e., rifampicin, isoniazid, ...
The interventions affected the number of potential prescription omissions (OR, 0.50 [0.37–0.69]; p < 0.0001; four studies). No apparent reduction in the number of drug interactions within 2 months (OR, 0.84 [0.70–1.02]; p = 0.08; two studies) and mortality (OR, 0.92 [0.76–...
Quinine: Dosage adjustment of quinine not required; monitor closely for quinine-associated adverse effects Antimycobacterials (isoniazid, rifabutin, rifampin) Isoniazid: Possible decreased ketoconazole concentrations Rifabutin: Possible increased rifabutin concentrations; possible decreased ketoconazole concentrations ...
Atorvastatin, fluvastatin, simvastatin: Dosage adjustment of the statin may be necessary when phenytoin is added to or withdrawn from concomitant therapy Isoniazid Possible increased serum phenytoin concentrations Phenytoin toxicity reported in about 25% of patients receiving concomitant therapy Monitor serum...