Imatinib (brand names Gleevec [oral tablet], Imkeldi [oral solution]) is used to treat certain types of leukemia (blood cancer), bone marrow disorders, and skin cancer.Imatinib is also used to treat certain tumors of the stomach and digestive system....
Plasma concentration monitoring or dosage adjustment of imatinib may be necessary Immunosuppressive agents (e.g., cyclosporine, sirolimus, tacrolimus) Cyclosporine, sirolimus, tacrolimus: Carbamazepine may induce metabolism of and decrease plasma concentrations of these immunosuppressive agents Plasma concentrati...
Eligible patients were ≥ 18 years of age with Philadelphia chromosome-positive B-cell precursor ALL, relapsed or refractory to at least 1 second generation or later tyrosine kinase inhibitor (TKI), or intolerant to second generation TKI, and intolerant or refractory to imatinib mesylate. BLINCYTO ...
This kinase is constitutively active, and is the driver of nearly all chronic myeloid leukemias (CML). Therefore, patients with CML and are Ph+ can be matched to imatinib therapy. Imatinib therapy has been fairly successful for CML patients. It has been shown that patients who achieve complete...
Redberg, MD, MSc JAMA Comment & Response Evidence Required for Drugs Granted Accelerated Approval Tetsuya Tanimoto, MD; Kazuhiro Kosugi, MD; Kenji Tsuda, MD JAMA Comment & Response Evidence Required for Drugs Granted Accelerated Approval—Reply Huseyin Naci, PhD, MHS; Aaron S. Kesselheim, MD, ...
This device enables the detection of the anticancer agents Imatinib (IMA) and Erlotinib (ERL). Gold, platinum, and poly-l-methionine nanoparticles (AuPt, p-L-Met) were successfully coated onto the solid-phase extraction (SPE) using a single-step electrodeposition process from a solution ...
Prescription Medicines: Costs in Context. Washington, DC: Pharmaceutical Research and Manufacturers of America; 2017. 10. Abboud C, Berman E, Cohen A, et al; Experts in Chronic Myeloid Leukemia. The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices ...
such as imatinib [38]. In the age of –omics and big data, computational methods of repurposed drug screening are becoming increasingly favourable [40]. In signature matching screens, the proteomic, metabolomic, and genomic signatures of cancer cells can be compared with those of drug-treated ...
Arterial and venous thrombosis and occlusions occurred at least twice as often in patients receiving ponatinib compared to patients receiving imatinib. Patients receiving ponatinib also had a higher incidence of myelosuppression, pancreatitis, hepatotoxicity, cardiac failure, hypertension, and skin and subcuta...
May increase risk of tumor lysis syndrome, generally in patients with imatinib-resistant disease in an advanced phase.Due to potential for tumor lysis syndrome, maintain adequate hydration, correct uric acid levels prior to initiating therapy with dasatinib, and monitor electrolyte levels during therapy...