This may in turn reduce the risk of cardiovascular disease, which is over-represented amongst patients with RA, and for which hyperhomocysteinaemia is now recognized as an independent risk factor.“ If one cause of the elevated homocysteine levels is methotrexate, folic acid could help prevent th...
12.12.3.2.2Folic acid Folic acid(pteroylglutamic acid), along with choline, methionine, and homocysteine, is an essential player in one-carbon metabolism, and is well known as a dietary supplement used to protect against neural tube defects. Several drugs can alter maternal levels of folate by...
Folic acid (vitamin B9) is a B vitamin supplement that may be used to prevent and treat folate deficiency (low blood levels of folate) that can cause megaloblastic anemia. Folic acid may also be used to control high levels of homocysteine, prevent seriou
Lastly, doses of MTX and folic acid were not recorded in the database.Dermatologists were the least likely specialists to supplement MTX with folic acid. The evidence for supplementation of folic acid is mixed. The literature confirms a reduction in the adverse effects of MTX but less strongly...
and para-aminobenzoyl glutamic acid. Aminopterin and methotrexate, which have a structure similar to that of folic acid, are used in the treatment of certain types of malignant tumors. These compounds are antimetabolites of folic acid and have a suppressive effect on cell growth and development....
Research suggests the anticonvulsant action of phenytoin is antagonized by folic acid. A person whose epilepsy is controlled by phenytoin may require an increased dose if folic acid is given.Folic acid deficiency may be caused by the administration of folic acid antagonists, such as methotrexate, ...
depression and low folate levels may also not respond as well to antidepressants as people with adequate levels of the vitamin in their blood. Some studies show that increasing folate (or taking a folic acid supplement) in addition to anantidepressantmay help increase the effectiveness of the ...
The present study aimed to determine the folic acid supplement (FAS) effects on serum homocysteine and sortilin levels, glycemic indices, and lipid profile in type II diabetic patients. A double-blind randomized controlled clinical trial have been perfor
Foods with folic acid in them include leafy green vegetables, fruits, dried beans, peas and nuts. Enriched breads, cereals and other grain products also contain folic acid. If you don't get enough folic acid from the foods you eat, you can also take it as adietary supplement. ...
Folic acid antagonists Previously, folic acid antagonists, which are known to be highly embryolethal, were used in clinical trials as abortifacients (agents causing abortion). Although three-fourths of the pregnancies were terminated, almost one-fourth of the embryos that survived to term were ...