Part II. Discusses some of the benefits of folic acid in preventing colon cancer. Background on the Harvard research indicating lower incidence of colon cancer among those whose diets are rich in folic acid; Folate's major functions; ...
Reversal of megaloblastic anemia and prevention of congenital neural tube defects are the major goals of folic acid replacement therapy. Patients with malabsorption may be deficient in both folic acid and vitamin B12, and administration of folic acid alone may precipitate acute vitamin B12 deficiency....
Folic acid antagonists Previously, folic acid antagonists, which are known to be highly embryolethal, were used in clinical trials as abortifacients (agents causing abortion). Although three-fourths of the pregnancies were terminated, almost one-fourth of the embryos that survived to term were ...
g Quantitative results of fluorescence intensity of tumors and major organs of MHCF NPs Full size image The MRI and FLI functions of MHCF NPs were tested by in vitro experiments. We successfully verified that the nanocomposites have excellent imaging and targeting effects in the tumor acidic ...
Twenty-one malformations were categorized as major defects (6 with known genetic cause), 6 were minor, and 2 could not be classified. Adverse events were more frequent in the folic acid and zinc group (32% vs 27% in the placebo group), reflective of more frequent gastrointestinal symptoms ...
These suggest that folic acid-modified TPGS (FA-TPGS) can be used to encapsulate siXBP1s to target hepatic pro-inflammatory macrophages. Herein, we prepared hybrid FA-TPGS by a simple cross-linking action for stable and effective delivery of siRNA to specifically knockdown XBP1 (named FT@XBP1)...
Tetrahydrobiopterin is involved in many other biochemical functions, many of which have been just recently discovered. The term arginine, if not explicitly defined otherwise, always refers to the natural and unnatural stereoisomeric form of arginine. L-arginine, a natural amino acid, is the precursor...
In this letter to the Lancet from the New York Medical College attention is drawn to the fact that folic acid deficiency is an important, heretofore unsuspected, limiting factor in many patients with thalassaemia major. This is particularly the case when these patients require frequent blood transf...
These transporters are members of a large, phylogenetically distributed transporter superfamily, called “major facilitator superfamily” (MFS) (595). Members of this superfamily are involved in functions such as sugar uptake, drug efflux, and oligosaccharide–H+ symport. SLC19 members are rather ...
This is another major potential obstacle preventing this tumor therapy from entering clinical trials. However, the success of our mouse experiments has demonstrated the potential of this drug delivery system, and further studies will be conducted in the context of the human tumor microenvironment in ...