However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future ...
Fatigue was also a relevant side-effect present in all the patients, grade 1 in most of them but grade 3 or higher in 21 patients. Dose of chemotherapy was reduced in 37 patients. In 6 of them the reason for a reduction was peripheral neuropathy. 36 patients had a response, 11 stable...
Furthermore, given the complexity of pancreatectomy, patients may experience a prolonged postoperative recovery precluding timely administration of adjuvant chemotherapy; thus, preoperative therapy may enable use of systemic treatment for patients who would otherwise not receive it. To our knowledge, there ...
The lack of severe side effects in humans has been documented in one cohort of 20 patients with oral cancer34. Strategies for integrating CAP treatment and chemotherapy have been emerging through in vitro combination studies over the last few years. CAP has already been combined in vitro and in...
Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma(PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based regimens such as AG regimen (albumin paclitaxel and gemcitabine), fluorou
Encapsulation of drugs in nanocarriers that selectively target cancer cells promises to be an effective method for co-delivery of drug combinations and to mitigate the side effects of conventional chemotherapy. Here we reported the development of multiple layer-by-layer lipid-polymer hybrid nanoparticles...
Treatment toxicity was evaluated during medical visit by experienced physicians after four to six cycles of chemotherapy and at progression. All side-effects were graded according to the Common Terminology Criteria for Adverse Events version (CTCAE) version 4 [17]. 2.4. Anthropometric Measurement For ...