However, there appears to be subsets of patients who derive considerable benefit: Asians, women, nonsmokers, adenocarcinoma patients, and those with EGFR mutations. Mechanism of action In addition to its inhibition of the tyrosine kinase activity of EGFR, gefitinib may also inhibit the activity of...
thesecondinwomen(614000cases,9.2%ofthecan),andFOLFOX4(folinicacid/fluorouracil/oxali- total)worldwidein2012accordingtothestatisticstin)havebeenestablishedasstandardtreatmentsof publishedbyWorldHealthOrganization.1Radical6 advancedCRCthusfar.Nevertheless,theyshowonly ...
While FOLFIRI is associated with severe diarrhoea and neutropenia [7], EGFR inhibitors are associated with unique side effects, mostly different to those seen during chemotherapy. Because of the key role of EGFR signalling in skin [8], anti-EGFR therapy frequently results in integument-related ...