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where, FGG and FGR are the background-corrected fluorescence intensities in the donor and acceptor channel after donor excitation respectively and FRR is the background-corrected fluorescence signal in red channel after acceptor excitation. For the determined correction factors, see Table S2. Ideally,...
1c, d and Supplementary Table 1). These results suggest that the posttranslational conformational ensembles, including the folding intermediates of all core domains are required to support the drug-induced native fold selection of CFTR. Uncoupling NBD1-TMD1/2 interface misfolds CFTR Although the ...
Full size image Tissue curvature regulates the spatiotemporal dynamics of folding Having investigated the role of in-plane tension, we next challenged the role of curvature by testing whether modulating the local tissue curvature would result in changes in deepening speed. Toward this goal, we develo...
Table S4. The average lDDT of the EFR for β-sheet, α-helix, and α/β type protein intermediates are 0.778, 0.707, and 0.727, respectively, which are 32.4, 24.7, and 28.9% higher than the LFR respectively. It is obvious that the EFR of β-sheet folds the fastest, whereas the LFR...
Table 1.Some biophysical techniques for the study of protein folding and their features. TechnicFeaturesBasis of measurementParameter Circular dichroismGeneral, insensitive, low resolution, slowCircularly polarized lightMolar ellipticity FluorescenceSensitive, low resolution, few fluorophores, fastEmitted lightFlu...
The above is implemented by the built-in data set. If you are using the Oracle data set, you can use selectdistinct large category, small category from table name, and then left join the same table, get the value data needed in it, and then place it where needed You may need to con...
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