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Protein misfoldingcan lead to neurodegenerative diseases such as Parkinson's, Alzheimer's and Creutzfeldt–Jakob disease (CJD). A new technique designed by Laurence Barron (Glasgow University, UK) has revealed a conformational change in a model protein that results in fibrillar aggregation, similar t...
The research object of this paper is a newly designed VTOL UAV that can change rotor pull direction by folding its wings, meaning that the UAV can switch between quadrotor mode and fixed-wing mode. This deformable feature gives the UAV both vertical take-off and landing ability and fast cruis...
“I’m not afraid that you’ll laugh at me.” Qin Tian paced back and forth in front of Lao Dao. “When you see her, you’ll understand the meaning of ‘peerless elegance.’” Qin Tian stopped, sinking into a reverie. He was thinking of Yi Yan’s mouth. Her mouth was perhaps hi...
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Although phi-value analysis has provided great insight into many systems, it still suffers from the imprecise meaning of intermediate phi-values and the obvious limitation of trying to extract kinetic information from thermodynamic data (19, 20, 21). Deriving mechanistic information from pure MD ...
As in the previous testing, I plotted a pair of boundary lines to capture the 95% confidence interval, meaning that assuming a Gaussian distribution of data points, 95% of the work units will perform between in this boundary region. AMD Ryzen 9 3950X Folding@Home Performance: Core ...
We considered the possibility of intramolecular disulfide bonds as an alternative origin of the broad distributions of populations that we observed in both ensemble and single-molecule experiments. The I27 monomer is 89 residues long, and contains Cys residues at positions 47 and 63, meaning that ...
During the evolution, some proteins may undergo conservative changes in structure, that is, maintain similar structures during evolution because they perform similar functions. Other proteins may undergo innovative changes in structure, meaning they undergo structural remodeling to adapt to new environments...