A suture display rack and procedure kit is provided which, upon folding, presents a plurality of stacked suture packages for seriatim review. The suture display rack is a substantially U-shaped structure with a floor portion and two oppo... ...
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7) as the residue undergoing the critical protonation reaction required for prion misfolding and oligomerization. A more recent study51 shows indeed, that substituting His186 with the non-polar Phe in mouse PrP reduces the rate of misfolding, whereas the pathogenic H186R mutation has the ...
(TablesS2,S3); we thus adopt ProteinMPNN for our primary results. While generating more candidate sequences leads to a higher scTM score (as there are more chances to encounter a successfully folded sequence), we conservatively choose to run 8 samples to be directly comparable to ref.15. We...
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The best fit values for the differences in extension and free energy between N and U,ΔXN-U = 31.2 ± 2.6 nm and ΔGN-U = 16.6 ± 2.8 kcal/mol, are in agreement with the results of the HMM analysis, Tables 1 and 2. The equilibrium force (F1/2 = 7.4 pN) corresponding to a ...