Brain Uptake of Folate Forms in the Presence of Folate Receptor Alpha Antibodies in Young Rats: Folate and Antibody Distributionfolatefolate receptor alphalevofolinatebrain uptakeautismcerebral folate deficiencyIn a rat model, following exposure to rat folate receptor alpha antibodies (FRαAb...
Intracellular import of folate is dependent upon the function of two primary transport proteins: Reduced Folate Carrier 1 (RFC1/gene name:SLC19a1) andFolate Receptor 1(FOLR1). RFC1 is a bidirectional transmembrane transporter, moving primarily reduced forms of folate into and out of cells. RFC...
Folate metabolism impairment by coadministration of the thymidylate synthase inhibitor PMX and farletuzumab, a monoclonal folate receptor-targeting antibody, showed improved PFS rates. Therefore, simultaneous administration of chemotherapeutic agents with folate receptor inhibitors has prolonged survival in ...
V., and Sequeira, J. M. (2013b). Role of folate receptor autoantibodies in infantile autism. Mol. Psychiatry 18, 270-271. doi: 10.1038/mp.2012.22V.T. Ramaekers, E.V. Quadros, J.M. Sequeira, Role of folate receptor autoan- tibodies in infantile autism, Mol. Psychiatry 18 (2013) ...
The association of FR伪 AuAbs with pregnancy-related complications, CFD syndrome, and autism spectrum disorders and response to folate therapy is highly suggestive of the involvement of these AuAbs in the disruption of brain development and function via folate pathways. The two types of antibodies ...
Objective: We aim to investigate the behavioral deficits in rats exposed to folate receptor alpha antibodies (FRaAb) during fetal development. Furthermore, we aim to investigate the heritability of this autism spectrum disorder (ASD)-like phenotype by determining whether it is transmitted to a ...
The cerebral folate receptor alpha (FRα) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). CFD has been associated with autism spectrum disorders (ASD) and is treated with d,l-leucovorin (folinic acid). One cause...
Journal of Personalized Medicine Review Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis Daniel A. Rossignol 1,* and Richard E. Frye 2,3 1 Rossignol Medical Center, 24541 ...
The following supporting information can be downloaded at:https://www.mdpi.com/article/10.3390/nu14122397/s1. Table S1: MS/MS analysis for folate forms; Figure S1: Standard curve for measuring methlyfolate in tissues; Figure S2: Specificity of staining for folate receptor antibody in the fetal...
The following supporting information can be downloaded at:https://www.mdpi.com/article/10.3390/nu14122397/s1. Table S1: MS/MS analysis for folate forms; Figure S1: Standard curve for measuring methlyfolate in tissues; Figure S2: Specificity of staining for folate receptor antibody in the fetal...